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Target
Cytosol aminopeptidase
Ligand
BDBM50534075
Substrate
n/a
Meas. Tech.
ChEMBL_1927715 (CHEMBL4430787)
IC50
33600±n/a nM
Citation
 Ziemska, J; Gu?piel, A; Jarosz, J; Nasulewicz-Goldeman, A; Wietrzyk, J; Kaw?cki, R; Pypowski, K; Jaro?czyk, M; Solecka, J Molecular docking studies, biological and toxicity evaluation of dihydroisoquinoline derivatives as potential anticancer agents. Bioorg Med Chem 24:5302-5314 (2016) [PubMed]  Article 
Target
Name:
Cytosol aminopeptidase
Synonyms:
3.4.11.1 | 3.4.11.5 | 3.4.13.23 | AMPL_PIG | Cysteinylglycine-S-conjugate dipeptidase | LAP-3 | LAP3 | Leucine aminopeptidase 3 | Leucyl aminopeptidase | Proline aminopeptidase | Prolyl aminopeptidase
Type:
PROTEIN
Mol. Mass.:
56047.39
Organism:
Sus scrofa
Description:
ChEMBL_101481
Residue:
519
Sequence:
MFLLPLPAAARVAVRQLSVRRFWGPGPDAANMTKGLVLGIYSKEKEDDAPQFTSAGENFDKLVSGKLREILNISGPPLKAGKTRTFYGLHEDFSSVVVVGLGKKGAGVDDQENWHEGKENIRAAVAAGCRQIQDLEIPSVEVDPCGDAQAAAEGAVLGLYEYDELKQKKKVVVSAKLHGSGDQEAWQRGVLFASGQNLARHLMETPANEMTPTRFAEVIEKNLKSASSKTDVHIRPKSWIEEQEMGSFLSVAKGSEEPPVFLEIHYKGSPDASDPPLVFVGKGITFDSGGISIKASANMDLMRADMGGAATICSTIVSAAKLDLPINLVGLAPLCENMPSGKANKPGDVVRAKNGKTIQVDNTDAEGRLILADALCYAHTFNPKVIINAATLTGAMDIALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHYTKQIVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGMAGRPTRTLIEFLLRFSQDSA
  
Inhibitor
Name:
BDBM50534075
Synonyms:
CHEMBL4483393
Type:
Small organic molecule
Emp. Form.:
C29H29NO6
Mol. Mass.:
487.5437
SMILES:
CCOC(=O)C1(Cc2cc(OCc3ccccc3)cc(OCc3ccccc3)c2C=N1)C(=O)OCC |c:32|
Structure:
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