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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50534381
Substrate
n/a
Meas. Tech.
ChEMBL_1928565 (CHEMBL4431741)
IC50
11000±n/a nM
Citation
 Imperatore, C; Luciano, P; Aiello, A; Vitalone, R; Irace, C; Santamaria, R; Li, J; Guo, YW; Menna, M Structure and Configuration of Phosphoeleganin, a Protein Tyrosine Phosphatase 1B Inhibitor from the Mediterranean Ascidian Sidnyum elegans. J Nat Prod 79:1144-8 (2016) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50534381
Synonyms:
CHEMBL4569363
Type:
Small organic molecule
Emp. Form.:
C32H64NO11P
Mol. Mass.:
669.8244
SMILES:
CCCCCCCCCCCCCC[C@@H](OP(O)(O)=O)[C@@H](O)CC[C@@H](O)[C@@H](O)CC[C@@H](O)CCCCCCC(=O)NCC(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: