Target
Triosephosphate isomerase, glycosomal
Ligand
BDBM50534545
Substrate
n/a
Meas. Tech.
ChEMBL_1929124 (CHEMBL4432300)
IC50
77000±n/a nM
Citation
 Velázquez-López, JMHernández-Campos, AYépez-Mulia, LTéllez-Valencia, AFlores-Carrillo, PNieto-Meneses, RCastillo, R Synthesis and trypanocidal activity of novel benzimidazole derivatives. Bioorg Med Chem Lett 26:4377-81 (2016) [PubMed]  Article 
Target
Name:
Triosephosphate isomerase, glycosomal
Synonyms:
TIM | TPIS_TRYCR | Triose-phosphate isomerase
Type:
PROTEIN
Mol. Mass.:
27334.70
Organism:
Trypanosoma cruzi
Description:
ChEMBL_596695
Residue:
251
Sequence:
MASKPQPIAAANWKCNGSESLLVPLIETLNAATFDHDVQCVVAPTFLHIPMTKARLTNPKFQIAAQNAITRSGAFTGEVSLQILKDYGISWVVLGHSERRLYYGETNEIVAEKVAQACAAGFHVIVCVGETNEEREAGRTAAVVLTQLAAVAQKLSKEAWSRVVIAYEPVWAIGTGKVATPQQAQEVHELLRRWVRSKLGTDIAAQLRILYGGSVTAKNARTLYQMRDINGFLVGGASLKPEFVEIIEATK
  
Inhibitor
Name:
BDBM50534545
Synonyms:
CHEMBL4576576
Type:
Small organic molecule
Emp. Form.:
C14H10ClN5O5S2
Mol. Mass.:
427.843
SMILES:
COC(=O)c1cc2nc(SCC(=O)Nc3ncc(s3)[N+]([O-])=O)[nH]c2cc1Cl
Structure:
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