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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50535080
Substrate
n/a
Meas. Tech.
ChEMBL_1929832 (CHEMBL4433008)
IC50
800±n/a nM
Citation
 Lee, HW; Ryu, HW; Kang, MG; Park, D; Oh, SR; Kim, H Potent selective monoamine oxidase B inhibition by maackiain, a pterocarpan from the roots of Sophora flavescens. Bioorg Med Chem Lett 26:4714-4719 (2016) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_MOUSE | Amine oxidase [flavin-containing] B | MAO-B | Maob | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase type B
Type:
PROTEIN
Mol. Mass.:
58568.67
Organism:
Mus musculus
Description:
ChEMBL_605809
Residue:
520
Sequence:
MSNKSDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDNNNLWRTMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTKSTKQIATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQTGENVIVKTLNHEIYEAKYVISAIPPALGMKIHYSPPLPMLRNQLISRVPLGSVIKCMVYYKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGTYAAIMGFILAHKARKLVRLTKEERLRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVGKIFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESLDVPARPITSTFLERHLPSVPGLLKLFGLTTILSATALGFLAHKRGLFVHF
  
Inhibitor
Name:
BDBM50535080
Synonyms:
CHEMBL4453259
Type:
Small organic molecule
Emp. Form.:
C21H20O5
Mol. Mass.:
352.3805
SMILES:
[#6]-[#8]-c1ccc(cc1)-c1coc2cc(-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])c2c1=O
Structure:
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