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Target
Nuclear factor erythroid 2-related factor 2
Ligand
BDBM50535236
Substrate
n/a
Meas. Tech.
ChEMBL_1930089 (CHEMBL4433340)
EC50
650±n/a nM
Citation
 Jiang, ZY; Lu, MC; You, QD Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Inhibition: An Emerging Strategy in Cancer Therapy. J Med Chem 62:3840-3856 (2019) [PubMed]  Article 
Target
Name:
Nuclear factor erythroid 2-related factor 2
Synonyms:
NF-E2-related factor 2 | NF2L2_MOUSE | NFE2-related factor 2 | Nfe2l2 | Nrf-2 | Nrf2 | Nuclear factor erythroid 2-related factor 2 | Nuclear factor, erythroid derived 2, like 2 | Synonyms=Nrf2
Type:
PROTEIN
Mol. Mass.:
66864.12
Organism:
Mus musculus
Description:
ChEMBL_118338
Residue:
597
Sequence:
MMDLELPPPGLQSQQDMDLIDILWRQDIDLGVSREVFDFSQRQKDYELEKQKKLEKERQEQLQKEQEKAFFAQFQLDEETGEFLPIQPAQHIQTDTSGSASYSQVAHIPKQDALYFEDCMQLLAETFPFVDDHESLALDIPSHAESSVFTAPHQAQSLNSSLEAAMTDLSSIEQDMEQVWQELFSIPELQCLNTENKQLADTTAVPSPEATLTEMDSNYHFYSSISSLEKEVGNCGPHFLHGFEDSFSSILSTDDASQLTSLDSNPTLNTDFGDEFYSAFIAEPSDGGSMPSSAAISQSLSELLDGTIEGCDLSLCKAFNPKHAEGTMEFNDSDSGISLNTSPSRASPEHSVESSIYGDPPPGFSDSEMEELDSAPGSVKQNGPKAQPAHSPGDTVQPLSPAQGHSAPMRESQCENTTKKEVPVSPGHQKAPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVDDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLGHLKDEREKLLREKGENDRNLHLLKRRLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKPDTKKN
  
Inhibitor
Name:
BDBM50535236
Synonyms:
CHEMBL4459594
Type:
Small organic molecule
Emp. Form.:
C20H14FN3O2S
Mol. Mass.:
379.407
SMILES:
Fc1ccc(cc1)-c1csc2ncnc(NCc3ccc4OCOc4c3)c12
Structure:
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