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Target
Beta-secretase 1
Ligand
BDBM65867
Substrate
n/a
Meas. Tech.
ChEMBL_1930154 (CHEMBL4433405)
IC50
660±n/a nM
Citation
 Sharma, P; Tripathi, A; Tripathi, PN; Prajapati, SK; Seth, A; Tripathi, MK; Srivastava, P; Tiwari, V; Krishnamurthy, S; Shrivastava, SK Design and development of multitarget-directed N-Benzylpiperidine analogs as potential candidates for the treatment of Alzheimer's disease. Eur J Med Chem 167:510-524 (2019) [PubMed]  Article 
Target
Name:
Beta-secretase 1
Synonyms:
ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1)
Type:
Protein
Mol. Mass.:
55755.10
Organism:
Homo sapiens (Human)
Description:
P56817
Residue:
501
Sequence:
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
  
Inhibitor
Name:
BDBM65867
Synonyms:
(1-benzyl-4-piperidyl)-(4-chlorobenzyl)amine | 1-benzyl-N-(4-chlorobenzyl)-4-piperidinamine | 1-benzyl-N-[(4-chlorophenyl)methyl]piperidin-4-amine | MLS000974662 | N-[(4-chlorophenyl)methyl]-1-(phenylmethyl)-4-piperidinamine | N-[(4-chlorophenyl)methyl]-1-(phenylmethyl)piperidin-4-amine | SMR000496472 | cid_784405
Type:
Small organic molecule
Emp. Form.:
C19H23ClN2
Mol. Mass.:
314.852
SMILES:
Clc1ccc(CNC2CCN(Cc3ccccc3)CC2)cc1
Structure:
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