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Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Ligand
BDBM27507
Substrate
n/a
Meas. Tech.
ChEMBL_1930271 (CHEMBL4433522)
IC50
76000±n/a nM
Citation
 Farooqi, AS; Hong, JY; Cao, J; Lu, X; Price, IR; Zhao, Q; Kosciuk, T; Yang, M; Bai, JJ; Lin, H Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model. J Med Chem 62:4131-4141 (2019) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Synonyms:
NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3
Type:
Protein
Mol. Mass.:
43582.69
Organism:
Homo sapiens (Human)
Description:
Q9NTG7
Residue:
399
Sequence:
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
  
Inhibitor
Name:
BDBM27507
Synonyms:
3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacinamide | nicotinamide | pyridine-3-carboxamide
Type:
n/a
Emp. Form.:
C6H6N2O
Mol. Mass.:
122.1246
SMILES:
NC(=O)c1cccnc1
Structure:
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