Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 2
Ligand
BDBM50091650
Substrate
n/a
Meas. Tech.
ChEMBL_154174 (CHEMBL762378)
IC50
1±n/a nM
Citation
Balasubramaniam, A; Tao, Z; Zhai, W; Stein, M; Sheriff, S; Chance, WT; Fischer, JE; Eden, PE; Taylor, JE; Liu, CD; McFadden, DW; Voisin, T; Roze, C; Laburthe, M Structure-activity studies including a Psi(CH(2)-NH) scan of peptide YY (PYY) active site, PYY(22-36), for interaction with rat intestinal PYY receptors: development of analogues with potent in vivo activity in the intestine. J Med Chem 43:3420-7 (2000) [PubMed] Article
More Info.:
Target
Name:
Neuropeptide Y receptor type 2
Synonyms:
NPY-Y2 | NPY2R | Neuropeptide Y receptor type 2 | Neuropeptide Y/peptide YY-Y2 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42514.44
Organism:
RAT
Description:
NPY-Y2 NPY2R RAT::Q9ERC0
Residue:
381
Sequence:
MGPLGAEADENQTVEVKVELYGSGPTTPRGELPPDPEPELIDSTKLVEVQVVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSMTFKAKKNLEVKKNNGLTDSFSEATNV
Inhibitor
Name:
BDBM50091650
Synonyms:
Ala-Ser-Leu-Arg-His-Thi-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr | CHEMBL430274
Type:
Small organic molecule
Emp. Form.:
C84H137N29O21S
Mol. Mass.:
1921.233
SMILES:
CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccsc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O