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Target
Erythropoietin receptor
Ligand
BDBM50091851
Substrate
n/a
Meas. Tech.
ChEBML_67869
IC50
10000±n/a nM
Citation
 Connolly, PJ; Wetter, SK; Murray, WV; Johnson, DL; McMahon, FJ; Farrell, FX; Tullai, J; Jolliffe, LK Synthesis and erythropoietin receptor binding affinities of N,N-disubstituted amino acids. Bioorg Med Chem Lett 10:1995-9 (2001) [PubMed]  Article 
Target
Name:
Erythropoietin receptor
Synonyms:
EPO-R | EPOR | EPOR_HUMAN
Type:
PROTEIN
Mol. Mass.:
55040.56
Organism:
Homo sapiens (Human)
Description:
ChEMBL_67864
Residue:
508
Sequence:
MDHLGASLWPQVGSLCLLLAGAAWAPPPNLPDPKFESKAALLAARGPEELLCFTERLEDLVCFWEEAASAGVGPGNYSFSYQLEDEPWKLCRLHQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYHRVIHINEVVLLDAPVGLVARLADESGHVVLRWLPPPETPMTSHIRYEVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPVSLLTPSDLDPLILTLSLILVVILVLLTVLALLSHRRALKQKIWPGIPSPESEFEGLFTTHKGNFQLWLYQNDGCLWWSPCTPFTEDPPASLEVLSERCWGTMQAVEPGTDDEGPLLEPVGSEHAQDTYLVLDKWLLPRNPPSEDLPGPGGSVDIVAMDEGSEASSCSSALASKPSPEGASAASFEYTILDPSSQLLRPWTLCPELPPTPPHLKYLYLVVSDSGISTDYSSGDSQGAQGGLSDGPYSNPYENSLIPAAEPLPPSYVACS
  
Inhibitor
Name:
BDBM50091851
Synonyms:
(S)-6-Amino-2-((3-benzyloxy-benzyl)-{(E)-3-[3-(4-tert-butyl-phenoxy)-phenyl]-propenyl}-amino)-hexanoic acid methyl ester | CHEMBL303757
Type:
Small organic molecule
Emp. Form.:
C40H48N2O4
Mol. Mass.:
620.8201
SMILES:
COC(=O)[C@H](CCCCN)N(Cc1cccc(OCc2ccccc2)c1)\C=C\Cc1cccc(Oc2ccc(cc2)C(C)(C)C)c1
Structure:
Search PDB for entries with ligand similarity: