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Target
Serine/threonine-protein kinase pim-1/pim-2/pim-3
Ligand
BDBM50536098
Substrate
n/a
Meas. Tech.
ChEMBL_1932814 (CHEMBL4478466)
IC50
127±n/a nM
Citation
 Pettus, LH; Andrews, KL; Booker, SK; Chen, J; Cee, VJ; Chavez, F; Chen, Y; Eastwood, H; Guerrero, N; Herberich, B; Hickman, D; Lanman, BA; Laszlo, J; Lee, MR; Lipford, JR; Mattson, B; Mohr, C; Nguyen, Y; Norman, MH; Powers, D; Reed, AB; Rex, K; Sastri, C; Tamayo, N; Wang, P; Winston, JT; Wu, B; Wu, T; Wurz, RP; Xu, Y; Zhou, Y; Tasker, AS; Wang, HL Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors. J Med Chem 59:6407-30 (2016) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1/pim-2/pim-3
Synonyms:
Serine/threonine-protein kinase PIM
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 2135988
Components:
This complex has 3 components.
Component 1
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Component 2
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Component 3
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM50536098
Synonyms:
CHEMBL4587256
Type:
Small organic molecule
Emp. Form.:
C20H23N5O3
Mol. Mass.:
381.4283
SMILES:
C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC(C)(C)CO)n(C)c2=O |r|
Structure:
Search PDB for entries with ligand similarity: