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Target
Serine/threonine-protein kinase 26
Ligand
BDBM50536679
Substrate
n/a
Meas. Tech.
ChEMBL_1934101 (CHEMBL4479753)
IC50
6.3±n/a nM
Citation
 Sloman, DL; Noucti, N; Altman, MD; Chen, D; Mislak, AC; Szewczak, A; Hayashi, M; Warren, L; Dellovade, T; Wu, Z; Marcus, J; Walker, D; Su, HP; Edavettal, SC; Munshi, S; Hutton, M; Nuthall, H; Stanton, MG Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties. Bioorg Med Chem Lett 26:4362-6 (2016) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase 26
Synonyms:
MASK | MST4 | STK26 | STK26_HUMAN | Serine/threonine-protein kinase MST4
Type:
PROTEIN
Mol. Mass.:
46517.68
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1510631
Residue:
416
Sequence:
MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP
  
Inhibitor
Name:
BDBM50536679
Synonyms:
CHEMBL4568087
Type:
Small organic molecule
Emp. Form.:
C21H23N7OS
Mol. Mass.:
421.519
SMILES:
Cn1cc(cn1)-c1cnc2c(cnn2c1)-c1csc(c1)C(=O)N[C@@H]1CCCC[C@@H]1N |r|
Structure:
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