Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 4
Ligand
BDBM50092546
Substrate
n/a
Meas. Tech.
ChEMBL_3573 (CHEMBL620706)
Ki
2±n/a nM
Citation
 Curtet, S; Soulier, JL; Zahradnik, I; Giner, M; Berque-Bestel, I; Mialet, J; Lezoualc'h, F; Donzeau-Gouge, P; Sicsic, S; Fischmeister, R; Langlois, M New arylpiperazine derivatives as antagonists of the human cloned 5-HT(4) receptor isoforms. J Med Chem 43:3761-9 (2000) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 4
Synonyms:
5-HT-4 | 5-HT4 | 5-HT4S | 5-HT4a | 5-HT4b | 5-HT4c | 5-HT4d | 5-HT4hb | 5-hydroxytryptamine receptor 4 | 5-hydroxytryptamine receptor 4 (5-HT4) | 5HT4R_HUMAN | HTR4 | Serotonin (5-HT) receptor | Serotonin (5-HT3) receptor | Serotonin 4 (5-HT4) receptor | Serotonin Receptor 4
Type:
Enzyme
Mol. Mass.:
43767.54
Organism:
Homo sapiens (Human)
Description:
Q13639
Residue:
388
Sequence:
MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
  
Inhibitor
Name:
BDBM50092546
Synonyms:
4-Amino-5-chloro-2-methoxy-benzoic acid 2-[4-(6-chloro-pyridazin-3-yl)-piperazin-1-yl]-ethyl ester | CHEMBL330848
Type:
Small organic molecule
Emp. Form.:
C18H21Cl2N5O3
Mol. Mass.:
426.297
SMILES:
COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(CC1)c1ccc(Cl)nn1
Structure:
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