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Target
4-hydroxyphenylpyruvate dioxygenase
Ligand
BDBM50536970
Substrate
n/a
Meas. Tech.
ChEMBL_1935273 (CHEMBL4481032)
IC50
143±n/a nM
Citation
 Ndikuryayo, F; Kang, WM; Wu, FX; Yang, WC; Yang, GF Hydrophobicity-oriented drug design (HODD) of new human 4-hydroxyphenylpyruvate dioxygenase inhibitors. Eur J Med Chem 166:22-31 (2019) [PubMed]  Article 
Target
Name:
4-hydroxyphenylpyruvate dioxygenase
Synonyms:
4-hydroxyphenylpyruvate dioxygenase | 4-hydroxyphenylpyruvic acid oxidase | 4HPPD | HPD | HPPD_HUMAN | PPD
Type:
PROTEIN
Mol. Mass.:
44937.33
Organism:
Homo sapiens (Human)
Description:
ChEMBL_123
Residue:
393
Sequence:
MTTYSDKGAKPERGRFLHFHSVTFWVGNAKQAASFYCSKMGFEPLAYRGLETGSREVVSHVIKQGKIVFVLSSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDYIVQKARERGAKIMREPWVEQDKFGKVKFAVLQTYGDTTHTLVEKMNYIGQFLPGYEAPAFMDPLLPKLPKCSLEMIDHIVGNQPDQEMVSASEWYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIFTKPVQDRPTLFLEVIQRHNHQGFGAGNFNSLFKAFEEEQNLRGNLTNMETNGVVPGM
  
Inhibitor
Name:
BDBM50536970
Synonyms:
CHEMBL4537208
Type:
Small organic molecule
Emp. Form.:
C20H16Cl2O4
Mol. Mass.:
391.245
SMILES:
OC1=C(C(=O)c2cccc(OCc3ccc(Cl)cc3Cl)c2)C(=O)CCC1 |c:1|
Structure:
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