Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50536986
Substrate
n/a
Meas. Tech.
ChEMBL_1935275 (CHEMBL4481034)
Ki
72±n/a nM
Citation
 Intagliata, S; Alsharif, WF; Mesangeau, C; Fazio, N; Seminerio, M; Xu, YT; Matsumoto, RR; McCurdy, CR Benzimidazolone-based selective ? Eur J Med Chem 165:250-257 (2019) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50536986
Synonyms:
CHEMBL4580186
Type:
Small organic molecule
Emp. Form.:
C24H29FN4O2
Mol. Mass.:
424.5111
SMILES:
CC(=O)c1ccc2n(CCCCN3CCN(CC3)c3ccc(F)cc3)c(=O)n(C)c2c1
Structure:
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