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Target
Beta-lactamase
Ligand
BDBM50537179
Substrate
n/a
Meas. Tech.
ChEMBL_1935934 (CHEMBL4481693)
KON
20 M-1s-1
Citation
 Malico, AA; Dave, K; Adediran, SA; Pratt, RF Specificity of extended O-aryloxycarbonyl hydroxamates as inhibitors of a class C ?-lactamase. Bioorg Med Chem 27:1430-1436 (2019) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
AMPC_ENTCL | ampC
Type:
PROTEIN
Mol. Mass.:
41306.67
Organism:
Enterobacter cloacae
Description:
ChEMBL_40258
Residue:
381
Sequence:
MMRKSLCCALLLGISCSALATPVSEKQLAEVVANTITPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDAVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYHILEALQ
  
Inhibitor
Name:
BDBM50537179
Synonyms:
CHEMBL4593963
Type:
Small organic molecule
Emp. Form.:
C15H17F3N2O8
Mol. Mass.:
410.2993
SMILES:
OC(=O)C(F)(F)F.NC(=O)CCCCOC(=O)NOC(=O)Oc1ccccc1
Structure:
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