Reaction Details Report a problem with these data
Target
Histamine H4 receptor
Ligand
BDBM50537207
Substrate
n/a
Meas. Tech.
ChEMBL_1935952 (CHEMBL4481711)
Ki
725±n/a nM
Citation
 ?a?ewska, D; Mogilski, S; Hagenow, S; Kuder, K; G?uch-Lutwin, M; Siwek, A; Wi?cek, M; Kaleta, M; Seibel, U; Buschauer, A; Filipek, B; Stark, H; Kie?-Kononowicz, K Alkyl derivatives of 1,3,5-triazine as histamine H Bioorg Med Chem 27:1254-1262 (2019) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50537207
Synonyms:
CHEMBL4573929
Type:
Small organic molecule
Emp. Form.:
C12H22N6
Mol. Mass.:
250.3433
SMILES:
CCC(C)c1nc(N)nc(n1)N1CCN(C)CC1
Structure:
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