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Target
Growth factor receptor-bound protein 2
Ligand
BDBM50093125
Substrate
n/a
Meas. Tech.
ChEBML_63777
IC50
700±n/a nM
Citation
 Furet, P; Caravatti, G; Denholm, AA; Faessler, A; Fretz, H; García-Echeverría, C; Gay, B; Irving, E; Press, NJ; Rahuel, J; Schoepfer, J; Walker, CV Structure-based design and synthesis of phosphinate isosteres of phosphotyrosine for incorporation in Grb2-SH2 domain inhibitors. Part 1. Bioorg Med Chem Lett 10:2337-41 (2001) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Human
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50093125
Synonyms:
(4-{(S)-2-Acetylamino-2-[1-((1R,2S)-2-carbamoyl-cyclohexylcarbamoyl)-cyclohexylcarbamoyl]-ethyl}-benzyl)-phosphonic acid | CHEMBL78242
Type:
Small organic molecule
Emp. Form.:
C26H39N4O7P
Mol. Mass.:
550.5842
SMILES:
CC(=O)N[C@@H](Cc1ccc(CP(O)(O)=O)cc1)C(=O)NC1(CCCCC1)C(=O)N[C@@H]1CCCC[C@@H]1C(N)=O
Structure:
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