Reaction Details Report a problem with these data
Target
Casein kinase II subunit alpha 3
Ligand
BDBM23451
Substrate
n/a
Meas. Tech.
ChEMBL_1936186 (CHEMBL4481945)
IC50
200±n/a nM
Citation
 Battistutta, R; Lolli, G Inhibitory Properties of ATP-Competitive Coumestrol and Boldine Are Correlated to Different Modulations of CK2 Flexibility. J Nat Prod 82:1014-1018 (2019) [PubMed]  Article 
Target
Name:
Casein kinase II subunit alpha 3
Synonyms:
2.7.11.1 | CK II alpha 3 | CSK23_HUMAN | CSNK2A1P | CSNK2A3 | Casein kinase II alpha 1 polypeptide pseudogene | Casein kinase II subunit alpha 3
Type:
PROTEIN
Mol. Mass.:
45229.76
Organism:
Homo sapiens
Description:
ChEMBL_116899
Residue:
391
Sequence:
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWRLGCMLASMIFRKEPFFHGRDNYDQLVRIAKFLGTEDLYGYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANVMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAATGAQQ
  
Inhibitor
Name:
BDBM23451
Synonyms:
5,14-dihydroxy-8,17-dioxatetracyclo[8.7.0.0^{2,7}.0^{11,16}]heptadeca-1(10),2,4,6,11(16),12,14-heptaen-9-one | 7,12-Dihydroxycoumestan | CHEMBL30707 | Chrysanthin | Coumestrol | Cumoestrol | US8552057, 3
Type:
Coumestan
Emp. Form.:
C15H8O5
Mol. Mass.:
268.221
SMILES:
Oc1ccc2c(c1)oc1c2c(=O)oc2cc(O)ccc12
Structure:
Search PDB for entries with ligand similarity: