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Target
Casein kinase II subunit alpha 3
Ligand
BDBM50202318
Substrate
n/a
Meas. Tech.
ChEMBL_1936185 (CHEMBL4481944)
IC50
700±n/a nM
Citation
 Battistutta, R; Lolli, G Inhibitory Properties of ATP-Competitive Coumestrol and Boldine Are Correlated to Different Modulations of CK2 Flexibility. J Nat Prod 82:1014-1018 (2019) [PubMed]  Article 
Target
Name:
Casein kinase II subunit alpha 3
Synonyms:
2.7.11.1 | CK II alpha 3 | CSK23_HUMAN | CSNK2A1P | CSNK2A3 | Casein kinase II alpha 1 polypeptide pseudogene | Casein kinase II subunit alpha 3
Type:
PROTEIN
Mol. Mass.:
45229.76
Organism:
Homo sapiens
Description:
ChEMBL_116899
Residue:
391
Sequence:
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWRLGCMLASMIFRKEPFFHGRDNYDQLVRIAKFLGTEDLYGYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANVMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAATGAQQ
  
Inhibitor
Name:
BDBM50202318
Synonyms:
(+)-boldine | (S)-(+)-Boldine | (S)-1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol | CHEMBL388342 | boldine | cid_10154 | cid_248507
Type:
Small organic molecule
Emp. Form.:
C19H21NO4
Mol. Mass.:
327.3743
SMILES:
COc1cc-2c(C[C@@H]3N(C)CCc4cc(O)c(OC)c-2c34)cc1O |r|
Structure:
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