Reaction Details Report a problem with these data
Target
B2 bradykinin receptor
Ligand
BDBM50093765
Substrate
n/a
Meas. Tech.
ChEBML_40297
Kd
101000±n/a nM
Citation
 Artis, DR; Brotherton-Pleiss, C; Pease, JH; Lin, CJ; Ferla, SW; Newman, SR; Bhakta, S; Ostrelich, H; Jarnagin, K Structure-based design of six novel classes of nonpeptide antagonists of the bradykinin B2 receptor. Bioorg Med Chem Lett 10:2421-5 (2001) [PubMed]  Article 
Target
Name:
B2 bradykinin receptor
Synonyms:
B2 BRADYKININ | B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKR2 | BKRB2_HUMAN | Bradykinin B2 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44467.17
Organism:
Homo sapiens (Human)
Description:
B2 BRADYKININ BDKRB2 HUMAN::P30411
Residue:
391
Sequence:
MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ
  
Inhibitor
Name:
BDBM50093765
Synonyms:
(R)-3-Amino-N-(4-aminomethyl-benzyl)-2-{2-[(2-cyclohexyl-acetylamino)-methyl]-pyrrol-1-yl}-propionamide | CHEMBL310348
Type:
Small organic molecule
Emp. Form.:
C24H35N5O2
Mol. Mass.:
425.567
SMILES:
NC[C@H](C(=O)NCc1ccc(CN)cc1)n1cccc1CNC(=O)CC1CCCCC1
Structure:
Search PDB for entries with ligand similarity: