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Target
Cytochrome P450 2C19
Ligand
BDBM50538344
Substrate
n/a
Meas. Tech.
ChEMBL_1972621 (CHEMBL4605439)
IC50
>20000±n/a nM
Citation
Kokkonda, S; Deng, X; White, KL; El Mazouni, F; White, J; Shackleford, DM; Katneni, K; Chiu, FCK; Barker, H; McLaren, J; Crighton, E; Chen, G; Angulo-Barturen, I; Jimenez-Diaz, MB; Ferrer, S; Huertas-Valentin, L; Martinez-Martinez, MS; Lafuente-Monasterio, MJ; Chittimalla, R; Shahi, SP; Wittlin, S; Waterson, D; Burrows, JN; Matthews, D; Tomchick, D; Rathod, PK; Palmer, MJ; Charman, SA; Phillips, MA Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria. J Med Chem 63:4929-4956 (2020) [PubMed] Article
More Info.:
Target
Name:
Cytochrome P450 2C19
Synonyms:
(R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | CP2CJ_HUMAN | CYP2C19 | CYPIIC17 | CYPIIC19 | Cytochrome P450 2C19 (CYP2C19) | Cytochrome P450 2C19 [I331V] | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | P450-11A | P450-254C
Type:
Enzyme
Mol. Mass.:
55935.47
Organism:
Homo sapiens (Human)
Description:
P33261
Residue:
490
Sequence:
MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV