Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 11
Ligand
BDBM37953
Substrate
n/a
Meas. Tech.
ChEMBL_1977033 (CHEMBL4610168)
IC50
7300±n/a nM
Citation
 Li, X; Liu, J; Ma, L; Fu, P Pharmacological urate-lowering approaches in chronic kidney disease. Eur J Med Chem 166:186-196 (2019) [PubMed]  Article 
Target
Name:
Solute carrier family 22 member 11
Synonyms:
OAT4 | Organic anion transporter 4 | S22AB_HUMAN | SLC22A11
Type:
PROTEIN
Mol. Mass.:
59982.54
Organism:
Homo sapiens (Human)
Description:
ChEMBL_838708
Residue:
550
Sequence:
MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAVSTNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELRKVARINGHKEAKNLTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFSLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLGAMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLESQKSTAAQGNRQEAVTVESTSL
  
Inhibitor
Name:
BDBM37953
Synonyms:
US10093631, Compound Lesinurad | US10336710, Lesinurad | US10752613, Compound Lesinurad | US11020397, Compound Lesinurad | US11149013, Compound lesinurad | US11161835, Compound Lesinurad
Type:
Small organic molecule
Emp. Form.:
C17H14BrN3O2S
Mol. Mass.:
404.281
SMILES:
OC(=O)CSc1nnc(Br)n1-c1ccc(C2CC2)c2ccccc12 |(-2.97,1.02,;-1.83,-.01,;-2.15,-1.52,;-.36,.46,;-.04,1.97,;1.42,2.45,;1.9,3.91,;3.44,3.91,;3.91,2.45,;5.38,1.97,;2.67,1.54,;2.67,,;1.33,-.77,;1.33,-2.31,;2.67,-3.08,;2.67,-4.62,;3.44,-5.95,;1.9,-5.95,;4,-2.31,;5.33,-3.08,;6.67,-2.31,;6.67,-.77,;5.33,,;4,-.77,)|
Structure:
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