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Target
Beta-1 adrenergic receptor
Ligand
BDBM50538801
Substrate
n/a
Meas. Tech.
ChEMBL_1977178 (CHEMBL4610313)
EC50
1.4±n/a nM
Citation
 Yi, C; Xing, G; Wang, S; Li, X; Liu, Y; Li, J; Lin, B; Woo, AY; Zhang, Y; Pan, L; Cheng, M Design, synthesis and biological evaluation of 8-(2-amino-1-hydroxyethyl)-6-hydroxy-1,4-benzoxazine-3(4H)-one derivatives as potent ? Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51338.40
Organism:
Homo sapiens (Human)
Description:
P08588
Residue:
477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
  
Inhibitor
Name:
BDBM50538801
Synonyms:
CHEMBL4635163
Type:
Small organic molecule
Emp. Form.:
C22H29ClN2O5
Mol. Mass.:
436.929
SMILES:
Cl.COc1ccccc1CCC(C)(C)NC[C@H](O)c1cc(O)cc2NC(=O)COc12 |r|
Structure:
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