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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50094938
Substrate
n/a
Meas. Tech.
ChEMBL_162092 (CHEMBL767784)
IC50
18200±n/a nM
Citation
 Hamaguchi, T; Takahashi, A; Kagamizono, T; Manaka, A; Sato, M; Osada, H Synthesis and characterization of a potent and selective protein tyrosine phosphatase inhibitor, 2. Bioorg Med Chem Lett 10:2657-60 (2000) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50094938
Synonyms:
5-Isopropoxy-2-(4-methylsulfanyl-pyridin-2-ylmethanesulfinyl)-1H-benzoimidazole | 5-isopropoxy-2-((4-(methylthio)pyridin-2-yl)methylsulfinyl)-1H-benzo[d]imidazole | CHEMBL89067
Type:
Small organic molecule
Emp. Form.:
C17H19N3O2S2
Mol. Mass.:
361.482
SMILES:
CSc1ccnc(CS(=O)c2nc3ccc(OC(C)C)cc3[nH]2)c1
Structure:
Search PDB for entries with ligand similarity: