Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM50538989
Substrate
n/a
Meas. Tech.
ChEMBL_1977520 (CHEMBL4610655)
Ki
4440±n/a nM
Citation
 Asfaha, Y; Schrenk, C; Alves Avelar, LA; Lange, F; Wang, C; Bandolik, JJ; Hamacher, A; Kassack, MU; Kurz, T Novel alkoxyamide-based histone deacetylase inhibitors reverse cisplatin resistance in chemoresistant cancer cells. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50538989
Synonyms:
CHEMBL4639388
Type:
Small organic molecule
Emp. Form.:
C13H16Br2N2O4
Mol. Mass.:
424.085
SMILES:
ONC(=O)CCCCCONC(=O)c1cc(Br)cc(Br)c1
Structure:
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