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Target
Toll-like receptor 7
Ligand
BDBM50539349
Substrate
n/a
Meas. Tech.
ChEMBL_1977916 (CHEMBL4611051)
EC50
132±n/a nM
Citation
 Baba, A; Wakao, M; Shinchi, H; Chan, M; Hayashi, T; Yao, S; Cottam, HB; Carson, DA; Suda, Y Synthesis and immunostimulatory activity of sugar-conjugated TLR7 ligands. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Toll-like receptor 7
Synonyms:
TLR7_MOUSE | Tlr7
Type:
PROTEIN
Mol. Mass.:
121844.65
Organism:
Mus musculus
Description:
ChEMBL_933765
Residue:
1050
Sequence:
MVFSMWTRKRQILIFLNMLLVSRVFGFRWFPKTLPCEVKVNIPEAHVIVDCTDKHLTEIPEGIPTNTTNLTLTINHIPSISPDSFRRLNHLEEIDLRCNCVPVLLGSKANVCTKRLQIRPGSFSGLSDLKALYLDGNQLLEIPQDLPSSLHLLSLEANNIFSITKENLTELVNIETLYLGQNCYYRNPCNVSYSIEKDAFLVMRNLKVLSLKDNNVTAVPTTLPPNLLELYLYNNIIKKIQENDFNNLNELQVLDLSGNCPRCYNVPYPCTPCENNSPLQIHDNAFNSLTELKVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLAREIEEAKFLHFLPNLVELDFSFNYELQVYHASITLPHSLSSLENLKILRVKGYVFKELKNSSLSVLHKLPRLEVLDLGTNFIKIADLNIFKHFENLKLIDLSVNKISPSEESREVGFCPNAQTSVDRHGPQVLEALHYFRYDEYARSCRFKNKEPPSFLPLNADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSELWPLRELRYLDFSNNRLDLLYSTAFEELQSLEVLDLSSNSHYFQAEGITHMLNFTKKLRLLDKLMMNDNDISTSASRTMESDSLRILEFRGNHLDVLWRAGDNRYLDFFKNLFNLEVLDISRNSLNSLPPEVFEGMPPNLKNLSLAKNGLKSFFWDRLQLLKHLEILDLSHNQLTKVPERLANCSKSLTTLILKHNQIRQLTKYFLEDALQLRYLDISSNKIQVIQKTSFPENVLNNLEMLVLHHNRFLCNCDAVWFVWWVNHTDVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSVSISSVLFLMVVMTTSHLFFWDMWYIYYFWKAKIKGYQHLQSMESCYDAFIVYDTKNSAVTEWVLQELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKMAFYLSHQRLLDEKVDVIILIFLEKPLQKSKFLQLRKRLCRSSVLEWPANPQAHPYFWQCLKNALTTDNHVAYSQMFKETV
  
Inhibitor
Name:
BDBM50539349
Synonyms:
CHEMBL4636020
Type:
Small organic molecule
Emp. Form.:
C64H96N6O43
Mol. Mass.:
1637.4614
SMILES:
[H][C@@]12O[C@H](CO)[C@@H](O[C@@]3([H])O[C@H](CO)[C@@H](O[C@@]4([H])O[C@H](CO)[C@@]([H])(O[C@H]5O[C@H](CO)[C@@H](O[C@@]6([H])O[C@H](CO)[C@@]([H])(O[C@H]7O[C@H](CO)[C@@H](O[C@@]8([H])O[C@H](CNC(=O)c9ccc(Cn%10c(O)nc%11c(N)nc(OCCOC)nc%10%11)cc9)[C@@H](O[C@@]9([H])O[C@H](CO)[C@@H](O1)[C@H](O)[C@H]9O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O |r|
Structure:
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