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Target
Cyclin-dependent kinase 18
Ligand
BDBM50539721
Substrate
n/a
Meas. Tech.
ChEMBL_1978733 (CHEMBL4611868)
IC50
>8000±n/a nM
Citation
 Diab, S; Yu, M; Wang, S CDK7 Inhibitors in Cancer Therapy: The Sweet Smell of Success? J Med Chem 63:7458-7474 (2020) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 18
Synonyms:
2.7.11.22 | CDK18 | CDK18_HUMAN | Cell division protein kinase 18 | Cyclin-dependent kinase 18 | PCTAIRE-motif protein kinase 3 | PCTAIRE3 | PCTK3 | Serine/threonine-protein kinase PCTAIRE-3
Type:
PROTEIN
Mol. Mass.:
54437.90
Organism:
Homo sapiens
Description:
ChEMBL_117731
Residue:
474
Sequence:
MIMNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECSTFSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSIF
  
Inhibitor
Name:
BDBM50539721
Synonyms:
CHEMBL4635959
Type:
Small organic molecule
Emp. Form.:
C26H39N7O3
Mol. Mass.:
497.633
SMILES:
CC(C)c1cnn2c(NC3CCN(CC3)C(=O)O[C@H]3CCN(C3)C(=O)\C=C\CN(C)C)cc(C)nc12 |r|
Structure:
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