Reaction Details Report a problem with these data
Target
Oxysterols receptor LXR-alpha
Ligand
BDBM50539768
Substrate
n/a
Meas. Tech.
ChEMBL_1979295 (CHEMBL4612430)
Kd
20600±n/a nM
Citation
 Wang, J; Liang, Z; Li, K; Yang, B; Liu, Y; Fang, W; Tang, L; Zhou, X Ene-yne Hydroquinones from a Marine-derived Strain of the Fungus  J Nat Prod 83:1258-1264 (2020) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-alpha
Synonyms:
LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50403.85
Organism:
Homo sapiens (Human)
Description:
Q13133
Residue:
447
Sequence:
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50539768
Synonyms:
CHEMBL4641268
Type:
Small organic molecule
Emp. Form.:
C22H28O6
Mol. Mass.:
388.4541
SMILES:
[#6]-[#6@@H]-1-[#8]-[#6@@H](-[#8]-c2ccc(-[#8])c(c2)C#C[#6](=[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])-[#6@H](-[#8])-[#6@H](-[#8])-[#6@H]-1-[#8] |r|
Structure:
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