Reaction Details Report a problem with these data
Target
Casein kinase II subunit alpha'/beta
Ligand
BDBM50540034
Substrate
n/a
Meas. Tech.
ChEMBL_1979999 (CHEMBL4613134)
Ki
1466±n/a nM
Citation
 Lindenblatt, D; Nickelsen, A; Applegate, VM; Jose, J; Niefind, K Structural and Mechanistic Basis of the Inhibitory Potency of Selected 2-Aminothiazole Compounds on Protein Kinase CK2. J Med Chem 63:7766-7772 (2020) [PubMed]  Article 
Target
Name:
Casein kinase II subunit alpha'/beta
Synonyms:
Casein kinase II alpha''''/ beta | Casein kinase II alpha''/ beta | Casein kinase II alpha'/ beta
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 794696
Components:
This complex has 2 components.
Component 1
Name:
Casein kinase II subunit beta
Synonyms:
CK2N | CSK2B_HUMAN | CSNK2B | Casein kinase II subunit beta | Casein kinase II subunit beta (CK2 beta) | Casein kinase II subunit beta (CK2β) | G5A | Serine/threonine-protein kinase pim-2
Type:
Enzyme
Mol. Mass.:
24937.13
Organism:
Homo sapiens (Human)
Description:
P67870
Residue:
215
Sequence:
MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPDEELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPHMLFMVHPEYRPKRPANQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR
  
Component 2
Name:
Casein kinase II subunit alpha'
Synonyms:
CK2A2 | CSK22_HUMAN | CSNK2A2 | Casein kinase II alpha (prime) | Casein kinase II alpha' | Casein kinase II subunit alpha (CK2A2) | Casein kinase II subunit alpha (CSNK2A2)
Type:
Protein
Mol. Mass.:
41223.82
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
350
Sequence:
MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR
  
Inhibitor
Name:
BDBM50540034
Synonyms:
CHEMBL4647986
Type:
Small organic molecule
Emp. Form.:
C15H11N3O2S
Mol. Mass.:
297.332
SMILES:
OC(=O)c1cccc(Nc2nc(cs2)-c2ccccn2)c1
Structure:
Search PDB for entries with ligand similarity: