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Target
Tyrosine-protein kinase Lyn
Ligand
BDBM50540741
Substrate
n/a
Meas. Tech.
ChEMBL_1982691 (CHEMBL4615953)
IC50
<10.0±n/a nM
Citation
 Prati, F; Buonfiglio, R; Furlotti, G; Cavarischia, C; Mangano, G; Picollo, R; Oggianu, L; di Matteo, A; Olivieri, S; Bovi, G; Porceddu, PF; Reggiani, A; Garrone, B; Di Giorgio, FP; Ombrato, R Optimization of Indazole-Based GSK-3 Inhibitors with Mitigated hERG Issue and  ACS Med Chem Lett 11:825-831 (2020) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lyn
Synonyms:
JTK8 | LYN | LYN_HUMAN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn (LYN) | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn
Type:
Protein
Mol. Mass.:
58575.92
Organism:
Homo sapiens (Human)
Description:
P07948
Residue:
512
Sequence:
MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
  
Inhibitor
Name:
BDBM50540741
Synonyms:
CHEMBL4640019
Type:
Small organic molecule
Emp. Form.:
C20H22N4O3
Mol. Mass.:
366.4137
SMILES:
OCc1cncc(c1)-c1ccc2[nH]nc(C(=O)NCC3CCOCC3)c2c1
Structure:
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