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Target
Dual specificity protein kinase CLK1
Ligand
BDBM50540741
Substrate
n/a
Meas. Tech.
ChEMBL_1982693 (CHEMBL4615955)
IC50
13±n/a nM
Citation
 Prati, F; Buonfiglio, R; Furlotti, G; Cavarischia, C; Mangano, G; Picollo, R; Oggianu, L; di Matteo, A; Olivieri, S; Bovi, G; Porceddu, PF; Reggiani, A; Garrone, B; Di Giorgio, FP; Ombrato, R Optimization of Indazole-Based GSK-3 Inhibitors with Mitigated hERG Issue and  ACS Med Chem Lett 11:825-831 (2020) [PubMed]  Article 
Target
Name:
Dual specificity protein kinase CLK1
Synonyms:
CDC-like kinase 1 | CDC-like kinase 1 (CLK1) | CDC2-like kinase 1 (CLK1) | CLK | CLK1 | CLK1_HUMAN | Dual specificity protein kinase CLK1 | Dual specificity protein kinase CLK1/CLK4 | Dual specificty protein kinase CLK1
Type:
Protein
Mol. Mass.:
57322.21
Organism:
Homo sapiens (Human)
Description:
P49759
Residue:
484
Sequence:
MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI
  
Inhibitor
Name:
BDBM50540741
Synonyms:
CHEMBL4640019
Type:
Small organic molecule
Emp. Form.:
C20H22N4O3
Mol. Mass.:
366.4137
SMILES:
OCc1cncc(c1)-c1ccc2[nH]nc(C(=O)NCC3CCOCC3)c2c1
Structure:
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