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Target
Cytoplasmic tyrosine-protein kinase BMX
Ligand
BDBM164638
Substrate
n/a
Meas. Tech.
ChEMBL_1983373 (CHEMBL4616779)
IC50
1.5±n/a nM
Citation
 Watterson, SH; Liu, Q; Beaudoin Bertrand, M; Batt, DG; Li, L; Pattoli, MA; Skala, S; Cheng, L; Obermeier, MT; Moore, R; Yang, Z; Vickery, R; Elzinga, PA; Discenza, L; D'Arienzo, C; Gillooly, KM; Taylor, TL; Pulicicchio, C; Zhang, Y; Heimrich, E; McIntyre, KW; Ruan, Q; Westhouse, RA; Catlett, IM; Zheng, N; Chaudhry, C; Dai, J; Galella, MA; Tebben, AJ; Pokross, M; Li, J; Zhao, R; Smith, D; Rampulla, R; Allentoff, A; Wallace, MA; Mathur, A; Salter-Cid, L; Macor, JE; Carter, PH; Fura, A; Burke, JR; Tino, JA Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK). J Med Chem 62:3228-3250 (2019) [PubMed]  Article 
Target
Name:
Cytoplasmic tyrosine-protein kinase BMX
Synonyms:
BMX | BMX non-receptor tyrosine kinase | BMX_HUMAN | Bone marrow tyrosine kinase gene in chromosome X protein | Cytoplasmic tyrosine-protein kinase BMX (BMX) | ETK | Epithelial and endothelial tyrosine kinase | NTK38 | Tyrosine Kinase BMX | Tyrosine-protein kinase BMX/ETK
Type:
Tyrosine-protein kinase
Mol. Mass.:
78030.42
Organism:
Homo sapiens (Human)
Description:
P51813
Residue:
675
Sequence:
MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKIRCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVLKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLREKDKH
  
Inhibitor
Name:
BDBM164638
Synonyms:
BDBM166759 | US10604504, Example 223 | US11623921, Example 223 | US9688629, 123 | US9802915, Example 123 | US9920031, Example 223
Type:
Small organic molecule
Emp. Form.:
C20H23FN4O2
Mol. Mass.:
370.4206
SMILES:
CC#CC(=O)N[C@H]1CCCN(C1)c1c(F)cc(C(N)=O)c2[nH]c(C)c(C)c12 |r|
Structure:
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