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Target
Substance-P receptor
Ligand
BDBM50097647
Substrate
n/a
Meas. Tech.
ChEBML_205876
Ki
620±n/a nM
Citation
 Aitken, DJ; Ongeri, S; Vallée-Goyet, D; Gramain, JC; Husson, HP Synthesis, modelling and NK1 antagonist evaluation of a non-rigid cyclopropane-containing analogue of CP-99,994. Bioorg Med Chem Lett 11:659-61 (2001) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50097647
Synonyms:
(3,5-Bis-trifluoromethyl-benzyl)-[1-(methylamino-phenyl-methyl)-cyclopropyl]-amine | CHEMBL158212
Type:
Small organic molecule
Emp. Form.:
C20H20F6N2
Mol. Mass.:
402.3766
SMILES:
CNC(c1ccccc1)C1(CC1)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Structure:
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