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Target
Histone deacetylase 8
Ligand
BDBM50541214
Substrate
n/a
Meas. Tech.
ChEMBL_1984004 (CHEMBL4617410)
IC50
4280±n/a nM
Citation
 Greenwood, SOR; Chan, AWE; Hansen, DF; Marson, CM Potent non-hydroxamate inhibitors of histone deacetylase-8: Role and scope of an isoindolin-2-yl linker with an ?-amino amide as the zinc-binding unit. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50541214
Synonyms:
CHEMBL4645826
Type:
Small organic molecule
Emp. Form.:
C17H19ClN2O2
Mol. Mass.:
318.798
SMILES:
Cl.N[C@H](Cc1ccc(O)cc1)C(=O)N1Cc2ccccc2C1 |r|
Structure:
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