Reaction Details Report a problem with these data
Target
Tyrosine--tRNA ligase, cytoplasmic
Ligand
BDBM50091497
Substrate
n/a
Meas. Tech.
ChEBML_226002
IC50
1.2±n/a nM
Citation
 Brown, P; Eggleston, DS; Haltiwanger, RC; Jarvest, RL; Mensah, L; O'Hanlon, PJ; Pope, AJ Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase. Bioorg Med Chem Lett 11:711-4 (2001) [PubMed]  Article 
Target
Name:
Tyrosine--tRNA ligase, cytoplasmic
Synonyms:
SYYC_HUMAN | Tyrosyl-tRNA synthetase | YARS | YARS1
Type:
PROTEIN
Mol. Mass.:
59145.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_211030
Residue:
528
Sequence:
MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS
  
Inhibitor
Name:
BDBM50091497
Synonyms:
(S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-((2S,3S,4S,5S)-1,3,4,5-tetrahydroxy-piperidin-2-yl)-acetic acid | CHEMBL51499 | [2-Amino-3-((S)-4-hydroxy-phenyl)-propionylamino]-((2S,3S,4S,5S)-1,3,4,5-tetrahydroxy-piperidin-2-yl)-acetic acid
Type:
Small organic molecule
Emp. Form.:
C16H23N3O8
Mol. Mass.:
385.3691
SMILES:
N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]([C@H]1[C@H](O)[C@@H](O)[C@@H](O)CN1O)C(O)=O
Structure:
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