Reaction Details Report a problem with these data
Target
Tyrosine--tRNA ligase, cytoplasmic
Ligand
BDBM50097746
Substrate
n/a
Meas. Tech.
ChEBML_226002
IC50
2±n/a nM
Citation
Brown, P; Eggleston, DS; Haltiwanger, RC; Jarvest, RL; Mensah, L; O'Hanlon, PJ; Pope, AJ Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase. Bioorg Med Chem Lett 11:711-4 (2001) [PubMed] Article
More Info.:
Target
Name:
Tyrosine--tRNA ligase, cytoplasmic
Synonyms:
SYYC_HUMAN | Tyrosyl-tRNA synthetase | YARS | YARS1
Type:
PROTEIN
Mol. Mass.:
59145.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_211030
Residue:
528
Sequence:
MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS
Inhibitor
Name:
BDBM50097746
Synonyms:
(S)-[2-Amino-3-((S)-4-hydroxy-phenyl)-propionylamino]-((1R,5R,8S)-2,4,5,8-tetrahydroxy-7-oxa-2-aza-bicyclo[3.2.1]oct-3-yl)-acetic acid | CHEMBL161302
Type:
Small organic molecule
Emp. Form.:
C17H23N3O9
Mol. Mass.:
413.3792
SMILES:
N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C1C(O)[C@]2(O)CO[C@H]([C@H]2O)N1O)C(O)=O