Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM22541
Substrate
n/a
Meas. Tech.
ChEBML_86751
Ki
1.4±n/a nM
Citation
 Stark, H; Sippl, W; Ligneau, X; Arrang, JM; Ganellin, CR; Schwartz, JC; Schunack, W Different antagonist binding properties of human and rat histamine H3 receptors. Bioorg Med Chem Lett 11:951-4 (2001) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM22541
Synonyms:
Clobenpropit | N''-[(4-chlorophenyl)methyl]{[3-(1H-imidazol-5-yl)propyl]sulfanyl}methanimidamide | VUF 9153 | VUF-9153 | VUF9153
Type:
Small organic molecule
Emp. Form.:
C14H17ClN4S
Mol. Mass.:
308.83
SMILES:
NC(SCCCc1cnc[nH]1)=NCc1ccc(Cl)cc1 |w:11.12|
Structure:
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