Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50541724
Substrate
n/a
Meas. Tech.
ChEMBL_1985286 (CHEMBL4618692)
EC50
2080±n/a nM
Citation
 Mugnaini, C; Kostrzewa, M; Bryk, M; Mahmoud, AM; Brizzi, A; Lamponi, S; Giorgi, G; Ferlenghi, F; Vacondio, F; Maccioni, P; Colombo, G; Mor, M; Starowicz, K; Di Marzo, V; Ligresti, A; Corelli, F Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3- J Med Chem 63:7369-7391 (2020) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50541724
Synonyms:
CHEMBL4640710
Type:
Small organic molecule
Emp. Form.:
C24H32N4O5
Mol. Mass.:
456.5347
SMILES:
CC(=O)OCCCCn1c2cn(C)nc2c(O)c(C(=O)NC23CC4CC(CC(C4)C2)C3)c1=O |TLB:24:25:23.22.28:29,THB:24:23:30.25.26:29,26:25:22:28.27.29,26:27:30.25.24:22|
Structure:
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