Reaction Details Report a problem with these data
Target
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Ligand
BDBM50529751
Substrate
n/a
Meas. Tech.
ChEMBL_1986049 (CHEMBL4619455)
Kd
<10.0±n/a nM
Citation
 Cheng, J; Li, Y; Wang, X; Dong, G; Sheng, C Discovery of Novel PDE? Degraders for the Treatment of KRAS Mutant Colorectal Cancer. J Med Chem 63:7892-7905 (2020) [PubMed]  Article 
Target
Name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Synonyms:
3',5'-cyclic phosphodiesterase | GMP-PDE delta | PDE6D | PDE6D_HUMAN | PDED | Protein p17 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Type:
PROTEIN
Mol. Mass.:
17418.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105761
Residue:
150
Sequence:
MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV
  
Inhibitor
Name:
BDBM50529751
Synonyms:
CHEMBL4472979 | US10913710, Compound 16
Type:
Small organic molecule
Emp. Form.:
C30H39ClN6O4S2
Mol. Mass.:
647.251
SMILES:
CNc1nccc(CN(CC2CCNCC2)S(=O)(=O)c2ccc(cc2)S(=O)(=O)N(Cc2ccc(Cl)cc2)C2CCCC2)n1
Structure:
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