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Target
Histone deacetylase 7
Ligand
BDBM50397360
Substrate
n/a
Meas. Tech.
ChEMBL_1986255 (CHEMBL4619661)
IC50
>10000±n/a nM
Citation
 Hassan, MM; Israelian, J; Nawar, N; Ganda, G; Manaswiyoungkul, P; Raouf, YS; Armstrong, D; Sedighi, A; Olaoye, OO; Erdogan, F; Cabral, AD; Angeles, F; Altintas, R; de Araujo, ED; Gunning, PT Characterization of Conformationally Constrained Benzanilide Scaffolds for Potent and Selective HDAC8 Targeting. J Med Chem 63:8634-8648 (2020) [PubMed]  Article 
Target
Name:
Histone deacetylase 7
Synonyms:
HD7 | HDAC7 | HDAC7A | HDAC7_HUMAN | Histone acetylase 7 (HDAC7) | Histone deacetylase 7A | Human HDAC7
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
102942.62
Organism:
Homo sapiens (Human)
Description:
Q8WUI4
Residue:
952
Sequence:
MDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL
  
Inhibitor
Name:
BDBM50397360
Synonyms:
CHEMBL2170177 | US10188756, Compound CN110
Type:
Small organic molecule
Emp. Form.:
C17H16N2O3
Mol. Mass.:
296.3205
SMILES:
COc1ccc(Cn2ccc3ccc(cc23)C(=O)NO)cc1
Structure:
Search PDB for entries with ligand similarity: