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Target
Carbonic anhydrase 5A, mitochondrial
Ligand
BDBM50542364
Substrate
n/a
Meas. Tech.
ChEMBL_1986669 (CHEMBL4620216)
IC50
4970±n/a nM
Citation
 Aneja, B; Queen, A; Khan, P; Shamsi, F; Hussain, A; Hasan, P; Rizvi, MMA; Daniliuc, CG; Alajmi, MF; Mohsin, M; Hassan, MI; Abid, M Design, synthesis & biological evaluation of ferulic acid-based small molecule inhibitors against tumor-associated carbonic anhydrase IX. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 5A, mitochondrial
Synonyms:
CA-VA | CA5 | CA5A | CAH5A_HUMAN | Carbonate dehydratase VA | Carbonic Anhydrase VA | Carbonic anhydrase 5A (CA VA) | Carbonic anhydrase 5A, mitochondrial | Carbonic anhydrase 5A, mitochondrial precursor | Carbonic anhydrase V | Carbonic anhydrase VA (CA VA)
Type:
Enzyme
Mol. Mass.:
34755.54
Organism:
Homo sapiens (Human)
Description:
Human (cloned) isozyme
Residue:
305
Sequence:
MLGRNTWKTSAFSFLVEQMWAPLWSRSMRPGRWCSQRSCAWQTSNNTLHPLWTVPVSVPGGTRQSPINIQWRDSVYDPQLKPLRVSYEAASCLYIWNTGYLFQVEFDDATEASGISGGPLENHYRLKQFHFHWGAVNEGGSEHTVDGHAYPAELHLVHWNSVKYQNYKEAVVGENGLAVIGVFLKLGAHHQTLQRLVDILPEIKHKDARAAMRPFDPSTLLPTCWDYWTYAGSLTTPPLTESVTWIIQKEPVEVAPSQLSAFRTLLFSALGEEEKMMVNNYRPLQPLMNRKVWASFQATNEGTRS
  
Inhibitor
Name:
BDBM50542364
Synonyms:
CHEMBL4642730
Type:
Small organic molecule
Emp. Form.:
C20H19N3O4
Mol. Mass.:
365.3826
SMILES:
COc1cc(\C=C\C(O)=O)ccc1OCc1cn(nn1)-c1ccc(C)cc1
Structure:
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