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Target
Elastase
Ligand
BDBM50542688
Substrate
n/a
Meas. Tech.
ChEMBL_1987680 (CHEMBL4621227)
IC50
3500±n/a nM
Citation
 Konstantinovi?, J; Yahiaoui, S; Alhayek, A; Haupenthal, J; Schönauer, E; Andreas, A; Kany, AM; Müller, R; Koehnke, J; Berger, FK; Bischoff, M; Hartmann, RW; Brandstetter, H; Hirsch, AKH -Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting  J Med Chem 63:8359-8368 (2020) [PubMed]  Article 
Target
Name:
Elastase
Synonyms:
ELAS_PSEAE | Pseudolysin | lasB
Type:
PROTEIN
Mol. Mass.:
53687.94
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_619859
Residue:
498
Sequence:
MKKVSTLDLLFVAIMGVSPAAFAADLIDVSKLPSKAAQGAPGPVTLQAAVGAGGADELKAIRSTTLPNGKQVTRYEQFHNGVRVVGEAITEVKGPGKSVAAQRSGHFVANIAADLPGSTTAAVSAEQVLAQAKSLKAQGRKTENDKVELVIRLGENNIAQLVYNVSYLIPGEGLSRPHFVIDAKTGEVLDQWEGLAHAEAGGPGGNQKIGKYTYGSDYGPLIVNDRCEMDDGNVITVDMNSSTDDSKTTPFRFACPTNTYKQVNGAYSPLNDAHFFGGVVFKLYRDWFGTSPLTHKLYMKVHYGRSVENAYWDGTAMLFGDGATMFYPLVSLDVAAHEVSHGFTEQNSGLIYRGQSGGMNEAFSDMAGEAAEFYMRGKNDFLIGYDIKKGSGALRYMDQPSRDGRSIDNASQYYNGIDVHHSSGVYNRAFYLLANSPGWDTRKAFEVFVDANRYYWTATSNYNSGACGVIRSAQNRNYSAADVTRAFSTVGVTCPSAL
  
Inhibitor
Name:
BDBM50542688
Synonyms:
CHEMBL4633389
Type:
Small organic molecule
Emp. Form.:
C10H7F2NO2S
Mol. Mass.:
243.23
SMILES:
Fc1ccc(cc1F)N1C(=O)CC(S)C1=O
Structure:
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