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Target
N-terminal Xaa-Pro-Lys N-methyltransferase 1
Ligand
BDBM50542788
Substrate
n/a
Meas. Tech.
ChEMBL_1988001 (CHEMBL4621548)
Ki
6.8±n/a nM
Citation
 Chen, D; Dong, C; Dong, G; Srinivasan, K; Min, J; Noinaj, N; Huang, R Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogues. J Med Chem 63:8419-8431 (2020) [PubMed]  Article 
Target
Name:
N-terminal Xaa-Pro-Lys N-methyltransferase 1
Synonyms:
2.1.1.244 | Alpha N-terminal protein methyltransferase 1A | C9orf32 | METTL11A | Methyltransferase-like protein 11A | N-terminal RCC1 methyltransferase | N-terminal Xaa-Pro-Lys N-methyltransferase 1 | N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed | NRMT | NRMT1 | NRMT1 | NTM1A | NTM1A_HUMAN | NTMT1 | X-Pro-Lys N-terminal protein methyltransferase 1A
Type:
PROTEIN
Mol. Mass.:
25382.72
Organism:
Homo sapiens
Description:
ChEMBL_119192
Residue:
223
Sequence:
MTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISSIDINSSRKFLQRFLREGPNKTGTSCALDCGAGIGRITKRLLLPLFREVDMVDITEDFLVQAKTYLGEEGKRVRNYFCCGLQDFTPEPDSYDVIWIQWVIGHLTDQHLAEFLRRCKGSLRPNGIIVIKDNMAQEGVILDDVDSSVCRDLDVVRRIICSAGLSLLAEERQENLPDEIYHVYSFALR
  
Inhibitor
Name:
BDBM50542788
Synonyms:
CHEMBL4645959
Type:
Small organic molecule
Emp. Form.:
C44H76N18O11
Mol. Mass.:
1033.1882
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNCCN(CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(=O)N[C@@H](C)C(N)=O |r|
Structure:
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