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Target
Cysteine proteinase B
Ligand
BDBM50543687
Substrate
n/a
Meas. Tech.
ChEMBL_1989726 (CHEMBL4623461)
IC50
12900±n/a nM
Citation
 Costa, CA; Lopes, RM; Ferraz, LS; Esteves, GNN; Di Iorio, JF; Souza, AA; de Oliveira, IM; Manarin, F; Judice, WAS; Stefani, HA; Rodrigues, T Cytotoxicity of 4-substituted quinoline derivatives: Anticancer and antileishmanial potential. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Cysteine proteinase B
Synonyms:
LMCPB | LMCPB2.8 | LMCPB_LEIME
Type:
PROTEIN
Mol. Mass.:
47725.09
Organism:
Leishmania mexicana
Description:
ChEMBL_303092
Residue:
443
Sequence:
MATSRAALCAVAVVCVVLAAACAPARAIHVGTPAAALFEEFKRTYGRAYETLAEEQQRLANFERNLELMREHQARNPHAQFGITKFFDLSEAEFAARYLNGAAYFAAAKRHAAQHYRKARADLSAVPDAVDWREKGAVTPVKDQGACGSCWAFSAVGNIEGQWYLAGHELVSLSEQQLVSCDDMNDGCDGGLMLQAFDWLLQNTNGHLHTEDSYPYVSGNGYVPECSNSSELVVGAQIDGHVLIGSSEKAMAAWLAKNGPIAIALDASSFMSYKSGVLTACIGKQLNHGVLLVGYDMTGEVPYWVIKNSWGGDWGEQGYVRVVMGVNACLLSEYPVSAHVRESAAPGTSTSSETPAPRPVMVEQVICFDKNCTQGCRKTLIKANECHKNGGGGASMIKCSPQKVTMCTYSNEFCVGGGLCFETPDGKCAPYFLGSIMNTCHYT
  
Inhibitor
Name:
BDBM50543687
Synonyms:
CHEMBL4636701
Type:
Small organic molecule
Emp. Form.:
C24H21NOSe
Mol. Mass.:
418.39
SMILES:
[#6]-[#8]-c1ccc2nc(cc([Se;v2]c3ccccc3)c2c1)-c1c(-[#6])cccc1-[#6]
Structure:
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