Reaction Details Report a problem with these data
Target
Aurora kinase B
Ligand
BDBM50543802
Substrate
n/a
Meas. Tech.
ChEMBL_1989917 (CHEMBL4623652)
IC50
8330±n/a nM
Citation
 Al-Sanea, MM; Elkamhawy, A; Paik, S; Lee, K; El Kerdawy, AM; Syed Nasir Abbas, B; Joo Roh, E; Eldehna, WM; Elshemy, HAH; Bakr, RB; Ali Farahat, I; Alzarea, AI; Alzarea, SI; Alharbi, KS; Abdelgawad, MA Sulfonamide-based 4-anilinoquinoline derivatives as novel dual Aurora kinase (AURKA/B) inhibitors: Synthesis, biological evaluation and in silico insights. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50543802
Synonyms:
CHEMBL4644959
Type:
Small organic molecule
Emp. Form.:
C19H19N3O4S
Mol. Mass.:
385.437
SMILES:
CCOC(=O)c1cnc2ccc(C)cc2c1Nc1cccc(c1)S(N)(=O)=O
Structure:
Search PDB for entries with ligand similarity: