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Target
TYR_PHOSPHATASE_2 domain-containing protein
Ligand
BDBM50544111
Substrate
n/a
Meas. Tech.
ChEMBL_1991675 (CHEMBL4625410)
Ki
400±n/a nM
Citation
 de Souza, ACA; Mori, M; Sens, L; Rocha, RF; Tizziani, T; de Souza, LFS; Domeneghini Chiaradia-Delatorre, L; Botta, M; Nunes, RJ; Terenzi, H; Menegatti, ACO A chalcone derivative binds a putative allosteric site of YopH: Inhibition of a virulence factor of Yersinia. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
TYR_PHOSPHATASE_2 domain-containing protein
Synonyms:
(PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) | MPtpB | PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB | Phosphotyrosine protein phosphatase | Phosphotyrosine-protein phosphatase PTPB | Protein Tyrosine Phosphatase PTPB
Type:
Hydrolase
Mol. Mass.:
30152.45
Organism:
Mycobacterium tuberculosis
Description:
n/a
Residue:
276
Sequence:
MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSINDAATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
  
Inhibitor
Name:
BDBM50544111
Synonyms:
CHEMBL4638054
Type:
Small organic molecule
Emp. Form.:
C16H11NO5
Mol. Mass.:
297.2622
SMILES:
OC(=O)c1ccc(\C=C\C(=O)c2cccc(c2)[N+]([O-])=O)cc1
Structure:
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