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Target
Dual specificity protein phosphatase 10
Ligand
BDBM50544427
Substrate
n/a
Meas. Tech.
ChEMBL_1992570 (CHEMBL4626305)
IC50
>50000±n/a nM
Citation
 Ruddraraju, KV; Aggarwal, D; Niu, C; Baker, EA; Zhang, RY; Wu, L; Zhang, ZY Highly Potent and Selective  J Med Chem 63:9212-9227 (2020) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 10
Synonyms:
DUS10_HUMAN | DUSP10 | Dual specificity protein phosphatase 10 | MAP kinase phosphatase 5 | MKP-5 | MKP5 | Mitogen-activated protein kinase phosphatase 5 | Mitogen-activated protein kinase phosphatase 5 (MKP5)
Type:
Enzyme
Mol. Mass.:
52649.12
Organism:
Homo sapiens (Human)
Description:
Q9Y6W6
Residue:
482
Sequence:
MPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSANPGSNSHPPVIATTVVSLKAANLTYMPSSSGSARSLNCGCSSASCCTVATYDKDNQAQTQAIAAGTTTTAIGTSTTCPANQMVNNNENTGSLSPSSGVGSPVSGTPKQLASIKIIYPNDLAKKMTKCSKSHLPSQGPVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVMPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHENLCDNSLQLQECREVGGGASAASSLLPQPIPTTPDIENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRILTPKLMGVETVV
  
Inhibitor
Name:
BDBM50544427
Synonyms:
CHEMBL4632818 | US11192850, Entry 4g
Type:
Small organic molecule
Emp. Form.:
C19H16N2O6
Mol. Mass.:
368.3401
SMILES:
CN(C)c1cc(O)c(cc1C#Cc1cccc(NC(=O)C(O)=O)c1)C(O)=O
Structure:
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