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Target
Cholinesterase
Ligand
BDBM50544934
Substrate
n/a
Meas. Tech.
ChEMBL_1993991 (CHEMBL4627886)
IC50
41030±n/a nM
Citation
 Xu, Y; Jian, MM; Han, C; Yang, K; Bai, LG; Cao, F; Ma, ZY Design, synthesis and evaluation of new 4-arylthiazole-2-amine derivatives as acetylcholinesterase inhibitors. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Cholinesterase
Synonyms:
3.1.1.8 | Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase | CHLE_CANLF | Choline esterase II | Cholinesterase | Pseudocholinesterase
Type:
PROTEIN
Mol. Mass.:
15084.45
Organism:
Canis lupus familiaris
Description:
ChEMBL_119907
Residue:
141
Sequence:
NTDQSFPGFPGSEMWNPNTDLSEDCLYLNVWIPTPKPKNATVMIWIYGGGFQTGTSSLPVYDGKFLARVERVIVVSVNYRVGALGFLALPGNPEAPGNLGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAGSVGLHL
  
Inhibitor
Name:
BDBM50544934
Synonyms:
CHEMBL4645093
Type:
Small organic molecule
Emp. Form.:
C34H40N4O4S
Mol. Mass.:
600.771
SMILES:
COc1ccc(CC(=O)Nc2ncc(s2)-c2ccc(OCCCCN3CCN(Cc4ccccc4)CC3)cc2)cc1OC
Structure:
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