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Target
Tumor necrosis factor ligand superfamily member 11
Ligand
BDBM50547350
Substrate
n/a
Meas. Tech.
ChEMBL_2017729 (CHEMBL4671307)
Kd
19060±n/a nM
Citation
 Rinotas, V; Papakyriakou, A; Violitzi, F; Papaneophytou, C; Ouzouni, MD; Alexiou, P; Strongilos, A; Couladouros, E; Kontopidis, G; Eliopoulos, E; Douni, E Discovery of Small-Molecule Inhibitors of Receptor Activator of Nuclear Factor-?B Ligand with a Superior Therapeutic Index. J Med Chem 63:12043-12059 (2020) [PubMed]  Article 
Target
Name:
Tumor necrosis factor ligand superfamily member 11
Synonyms:
CD_antigen=CD254 | ODF | OPGL | RANKL | TNF11_HUMAN | TNFSF11 | TRANCE
Type:
PROTEIN
Mol. Mass.:
35484.75
Organism:
Homo sapiens
Description:
ChEMBL_106141
Residue:
317
Sequence:
MRRASRDYTKYLRGSEEMGGGPGAPHEGPLHAPPPPAPHQPPAASRSMFVALLGLGLGQVVCSVALFFYFRAQMDPNRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
  
Inhibitor
Name:
BDBM50547350
Synonyms:
CHEMBL3740948
Type:
Small organic molecule
Emp. Form.:
C29H24N4O4
Mol. Mass.:
492.5253
SMILES:
Nc1cccc(c1)-n1cc(C(=O)N2CCN(CC2)C(=O)c2coc3ccccc3c2=O)c2ccccc12
Structure:
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