Reaction Details Report a problem with these data
Target
Thyroid hormone receptor beta
Ligand
BDBM50105671
Substrate
n/a
Meas. Tech.
ChEBML_210495
Kd
4200±n/a nM
Citation
 Yoshihara, HA; Apriletti, JW; Baxter, JD; Scanlan, TS A designed antagonist of the thyroid hormone receptor. Bioorg Med Chem Lett 11:2821-5 (2001) [PubMed]  Article 
Target
Name:
Thyroid hormone receptor beta
Synonyms:
ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta
Type:
Receptor
Mol. Mass.:
52793.62
Organism:
Homo sapiens (Human)
Description:
Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1.
Residue:
461
Sequence:
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
  
Inhibitor
Name:
BDBM50105671
Synonyms:
CHEMBL97187 | {4-[(2,4-Dimethoxy-phenyl)-(4-hydroxy-3-isopropyl-phenyl)-methyl]-3,5-dimethyl-phenoxy}-acetic acid
Type:
Small organic molecule
Emp. Form.:
C28H32O6
Mol. Mass.:
464.5501
SMILES:
COc1ccc(C(c2ccc(O)c(c2)C(C)C)c2c(C)cc(OCC(O)=O)cc2C)c(OC)c1
Structure:
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